Injectable treatment
Polynucleotides in Newark
A consultation-led regenerative injectable for fine lines, crepey texture and loss of firmness, especially in delicate areas such as the eye area and mid-face.
- Price
- From £195 per session with Lydia, £250 with Mel or Dr Shahe. Course of three with Mel or Dr Shahe, £600
- Price
- From £195 per session with Lydia, £250 with Mel or Dr Shahe. Course of three with Mel or Dr Shahe, £600
- Duration
- 30 mins
- Downtime
- Usually minimal. Temporary swelling, redness or small injection-site marks can occur and usually settle quickly.
- Results
- Results tend to build gradually over several weeks as skin quality improves
- Longevity
- Varies by skin condition, treatment area and whether maintenance sessions are used
The treatment
Polynucleotides: how it works
Polynucleotides are purified nucleic-acid fragments used in regenerative injectable treatments. Unlike dermal filler, they do not add volume or change facial shape. Instead, they work over time to support skin repair processes, improve hydration and build elasticity. At The London Road Clinic they are particularly used for fine lines, crepey texture and reduced firmness in delicate areas such as the eye area and mid-face.
What patients notice
What to expect
- Supports skin repair and regeneration
- Improves hydration and elasticity over time
- Suitable for delicate areas where filler may not be the right fit
- No volumising effect
- Builds gradual, natural-looking improvement
Our patients
Before and after
Patients treated at The London Road Clinic, shown with their written consent. Faces are blurred or cropped to protect their privacy.
Individual results may vary.
Polynucleotides with SkinPen microneedling, under-eye area. Before on the left, after on the right. 
Polynucleotides with SkinPen microneedling, neck, side view. Before on the left, after on the right. 
Polynucleotides with SkinPen microneedling, neck, front view. Before above, after below. 
Polynucleotides with SkinPen microneedling, cheek and temple. Before on the left, after on the right. 
Polynucleotides with SkinPen microneedling, lower face, profile. Before on the left, after on the right.
Before you book
Is this treatment right for you?
Suitable for
- Adults who want skin-quality improvement for fine lines, crepey texture or reduced firmness, particularly in delicate facial areas.
Not suitable for
- Suitability must be checked in consultation. Treatment may not be appropriate during pregnancy or breastfeeding, with active skin infection or where there are other medical contraindications to injectable treatment.
In their own words
Every visit to London Road Clinic is wonderful, all the staff make you feel comfortable & relaxed. I’ve recently had a course of three Polynucleotide for my face. I was nervous & uncertain however Lydia gave me 100% confidence in her knowledge & experience which gave me complete trust in her.. The results in my skin are already showing… plumper, fewer deep lines and added radiance. Ageing is a privilege not given to everyone but in a world where we all strive to look our best, this treatment works wonders, the salmon DNA stimulates cell regeneration, collagen and elastin production. 100%
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After your appointment
Aftercare
Keep skincare gentle, use SPF and avoid heat, heavy exercise and excessive touching of the area for the period advised by your clinician. Follow all injectable aftercare guidance.
From the clinic shop
What we would send you home with
Polynucleotides are placed under the skin and work on repair over weeks. Keep the surface gentle while that happens: two calm, hydrating products, and two for the under-eye area this is often used on.
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Device
Dermalux LED Face Mask
At-home LED from Dermalux, whose units we use in clinic. Polynucleotides work over weeks, and this is what you can do at home across them.
£399.00 Buy now -
Skincare
HA-Revive Hyaluronic Drops 30 ml
Hyaluronic acid at the surface while the polynucleotides work underneath. Fast absorbing and does not block pores.
£96.00 Buy now -
Skincare
Phyto-Calm Aloe Drops 30 ml
Aloe and botanical oils for the days after injection, when your aftercare asks you to keep skincare gentle and avoid heat.
£64.00 Buy now -
Beauty
Under Eye Concealer 3.1g
Six shades, mineral, with vitamins C and E. For small injection marks under the eye once the area is no longer tender.
£37.00 Choose your shade
Prices are shown as they stand on our retail store and are confirmed at checkout. Product choice is a suggestion, not part of your treatment plan: your clinician's aftercare advice above comes first.
What they will not do
People arrive asking for polynucleotides because they have read they are the alternative to filler, which is half right. They do not add volume and they will not change the shape of your face, so if that is what you want you should have a different conversation. What they do is work on the quality of the skin itself, over a course. The people happiest with them wanted their skin to behave better rather than look different.
Lydia Griffin, Clinic Director
Two or three visits, a few weeks apart
The clinic is at 65 London Road, Newark-on-Trent, NG24 1RZ, with free parking at the front.
A short course, often around two to three sessions, spaced a few weeks apart. That is a manageable number of trips even from the edge of the county, and it is the whole commitment rather than the start of one.
The clinic is a short drive from Southwell, Bingham, Tuxford and Collingham, and the A1 and A46 bring West Bridgford, Keyworth, Lincoln, Grantham and Nettleham within range.
Small bumps at the injection points and some redness are expected on the day and settle. Under the eyes they are more visible than elsewhere, so plan the evening accordingly.
Further reading: the patient guide to polynucleotides, and how Profhilo, polynucleotides and skin boosters compare. Background on the concerns: under-eye concerns and fine lines and wrinkles.
Coming from Mansfield or Southwell? Each town has its own page with the distance and the route to Newark.
Common questions
Frequently asked about Polynucleotides
What do polynucleotides treat?
How do polynucleotides work?
Are polynucleotides the same as filler?
Which areas are commonly treated?
How many sessions are usually needed?
When will I see results?
Is there downtime after treatment?
Who may not be suitable for treatment?
Sources (3)
- The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review. Journal of Cosmetic Dermatology, 2025. PubMed 39645667
- Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives. Pharmaceutics, 2025. PubMed 40871045
- Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. International Journal of Molecular Sciences, 2024. PubMed 39125793
