Treatment comparison
Profhilo Skin Booster vs Profhilo Structura
Profhilo vs Profhilo Structura at The London Road Clinic, Newark. Understand the clinical difference and which is right for skin quality, volume loss or post-weight-loss facial changes.
Side by side
At a glance
| Compare | Profhilo Skin Booster | Profhilo Structura |
|---|---|---|
| Primary goal | Skin quality, hydration and elasticity | Structural firmness and fat pad regeneration |
| Injection depth | Dermis | Superficial fat layer (adipose tissue) |
| Delivery method | Needle at bio-remodelling points | Cannula |
| HA concentration | 64mg per 2ml | 90mg per 2ml |
| Best for | Crepey, dull or lax skin lacking quality and resilience | Structural sagging, volume loss, cheek deflation and jowling |
| Treats neck and hands | Yes, face, neck and hands | Face only |
| Sessions needed | 2 sessions, 4 weeks apart | 2 sessions, 30 days apart |
| Results timeline | Gradual improvement over several weeks | Initial firmness within days; peak definition 4 to 6 weeks after second session |
| Results duration | Around 6 months | 6 to 9 months |
| Downtime | Usually minimal; small injection bumps settle quickly | Usually minimal; mild swelling and tenderness settle within 24 to 72 hours |
| Price from | From £170 | From £350 |
The science
How each treatment works
Profhilo Skin Booster
Profhilo uses high-concentration hyaluronic acid placed in specific bio-remodelling points on the face, neck or hands. Rather than sculpting or adding bulk, the aim is to spread hydration, improve elasticity and rebuild overall skin quality over time. It works especially well for skin that feels crepey, dull or less resilient rather than primarily volume-depleted.
Full Profhilo Skin Booster details →Profhilo Structura
Profhilo Structura uses a thermally stabilised formulation of 90mg of high and low molecular weight hyaluronic acid per 2ml, a notably higher concentration than standard Profhilo. Rather than spreading through the dermis to improve surface skin quality, it is placed via cannula into the superficial fat layer beneath the skin: the adipose tissue responsible for facial contour and structural support. Once in place, it activates fat cells to behave more youthfully, stimulates collagen and elastin production and reorganises the extracellular matrix, restoring firmness and definition from within. The result is a natural structural lift rather than an added or sculpted volume. At The London Road Clinic, Profhilo Structura is particularly relevant for patients who have experienced significant facial fat pad deflation through ageing or rapid weight loss. For those who have lost facial volume as a result of GLP-1 receptor agonist medication, Structura directly addresses the adipose tissue affected, supporting structural restoration without artificial bulk.
Full Profhilo Structura details →Clinical perspective
Which is right for you?
Same manufacturer, different depth, different goal
Standard Profhilo works in the dermis to improve skin quality. Profhilo Structura works in the fat layer beneath to restore structural firmness. They treat different tissues and should not be used interchangeably.
Standard Profhilo places high-concentration HA at bio-remodelling points across the face, neck or hands and is designed to spread through the dermis, improving hydration, elasticity and skin resilience. It does not change the shape of the face or restore structural volume. The result is skin that looks and feels more hydrated, more resilient and healthier. Profhilo Structura goes deeper. It uses a higher HA concentration (90mg vs 64mg per 2ml) and is delivered by cannula into the superficial fat layer, the adipose tissue that maintains facial contour and structural support. Rather than improving surface skin quality, it activates fat cells to regenerate and reorganise, restoring the structural firmness and definition that volume loss removes.
Skin quality or structural sagging: the distinction matters
Crepey, dull or less firm skin points toward standard Profhilo. Visible sagging, cheek deflation, midface descent or jowling points toward Profhilo Structura.
The wrong choice for the right patient produces limited or no result. Standard Profhilo cannot address structural sagging because it does not reach the fat layer responsible for facial contour. Profhilo Structura is not appropriate where the concern is surface skin quality rather than structural deflation. Your clinician will identify which tissue layer is the source of the concern before recommending either treatment.
A note on post-weight-loss changes
Profhilo Structura is particularly well matched to patients who have experienced significant facial fat loss following rapid weight loss, including as a result of GLP-1 receptor agonist medication.
When weight loss depletes the facial fat layer, the face can look structurally deflated and aged in ways that skin-quality treatments cannot address. Structura targets the adipose tissue directly affected, making it a clinically relevant option for this presentation. Your clinician will advise at consultation whether Structura alone or in combination with dermal filler or other treatments is the appropriate approach for your degree of structural change.
Finding the right fit
Who each treatment suits
Profhilo Skin Booster
- Adults whose primary concern is skin quality: crepey texture, dullness or reduced elasticity rather than volume loss or structural sagging
- Those wanting improvement across the face, neck or hands without changing facial shape or structure
- Those in their thirties and forties noticing early skin quality changes who want a proactive maintenance approach
Profhilo Structura
- Adults with visible volume loss, midface sagging, cheek deflation, jowling or a structural hollowing rather than a skin-quality concern
- Those who have experienced significant facial fat pad depletion following rapid weight loss, including as a result of GLP-1 receptor agonist medication
- Those who have tried skin-quality treatments without addressing the structural loss underlying the appearance they want to change
Common questions
Frequently asked
Are Profhilo and Profhilo Structura the same product?
Which is better for facial ageing?
Can Profhilo Structura replace dermal filler?
Is Profhilo Structura suitable after significant weight loss?
Can both treatments be done at the same time?
How do the prices compare?
Are both treatments suitable during pregnancy?
Explore each treatment
Read the full treatment details
65 London Road, Newark
Still not sure which is right for you?
Your clinician will assess your skin, talk through both options and give you an honest recommendation, including if neither is the right choice. No obligation to proceed.
Medically reviewed by Dr Shahe Boghossian, Medical Consultant, GMC 5204600 . Last reviewed 23 May 2026.
